Daily Health

Ozempic Interactions with Food, Conditions, Alcohol & Drugs

Ozempic is an effective medication used to help manage blood sugar levels and assist in weight management. It’s essential to be aware of potential drug interactions when taking Ozempic since it may interact with other medications, supplements, and foods. 

Key takeaways:

  • Ozempic, also known as semaglutide or Wegovy, is a medication used for the treatment of type 2 diabetes and weight management, and it may interact with certain foods, medical conditions, and drugs.
  • It is important to inform your healthcare provider about any medications you are taking to assess potential interactions with Ozempic.
  • Some foods, particularly high-fat meals, may delay the absorption of Ozempic or affect its effectiveness. It is advisable to follow any dietary recommendations provided by your healthcare practitioner.
  • Medical conditions such as pancreatitis or a history of medullary thyroid carcinoma may require caution when using Ozempic. Discuss any underlying medical conditions with your healthcare provider to determine the appropriateness of using Ozempic.


You may wonder what drugs and foods interact with Ozempic. Certain medical conditions may increase your risk of adverse side effects while taking the medication. Read on to learn more about Ozempic interactions and how they can affect you.

Can you drink alcohol while on Ozempic?

Yes, you can drink alcohol while taking Ozempic, but you should be aware of potential side effects and the risks associated with combining this medication with other substances. Before drinking alcohol while taking Ozempic, it’s essential to consult your healthcare practitioner to ensure that you can safely do so.

Alcohol and Ozempic can both lower blood sugar levels and can therefore increase the risk of hypoglycemia or low blood sugar episodes when combined. These episodes may last for several hours and lead to symptoms such as nausea, sweating, confusion, and fatigue. That's why it’s recommended that people taking Ozempic limit their intake of alcoholic beverages to prevent hypoglycemic episodes from occurring. Additionally, since both drugs may cause a decrease in alertness or concentration levels, there is an increased risk of falls or injuries when taken together.

Individuals who consume alcohol while on Ozempic should talk with their healthcare practitioner. They may suggest limiting alcoholic beverages and eating something before drinking alcohol to reduce the risk of adverse reactions. Engaging in activities such as non-alcoholic events might benefit those treated with this medication.

There are many alternatives to drinking alcohol for those taking Ozempic that can still provide a pleasant evening or social gathering without fearing adverse reactions from mixing the two substances. 

Some examples include:

  • mocktails or flavoured waters instead of sugary drinks or juices 
  • light snacks that contain complex carbohydrates rather than processed snacks 
  • getting creative by making new recipes like smoothies and fruit salads 
  • playing fun games such as charades 
  • going out dancing 
  • listening to music (whether live or recorded) 
  • painting 
  • candle-making 
  • stargazing 
  • creating art projects like pottery
  • going on walks outdoors 
  • playing board games at home

Your options are endless!

Ultimately, it’s your choice if you want to have an occasional drink while taking treatment like Ozempic — but it’s always best to consult your healthcare practitioner before doing so to learn what is best for you based on your health factors and lifestyle habits.

What drugs cannot be taken with Ozempic?

Certain drugs taken with Ozempic may have potentially serious side effects, so it’s essential to be aware of the medications you shouldn’t take together. Before combining other drugs with Ozempic, please consult your healthcare practitioner or pharmacist to ensure safety. 

You should not take certain drugs with Ozempic due to the potentially severe side effects. These may include diuretics, MAOIs, NSAIDs, and SSRIs. Diuretics may increase the risk of dehydration, while MAOIs may lead to high blood pressure or serotonin syndrome.

Ozempic may interact negatively with other drugs, including:

  • antibiotics 
  • antifungals 
  • sulfonylureas 
  • corticosteroids
  • non-steroidal anti-inflammatory drugs (NSAIDs)
  • beta-blockers 
  • calcium channel blockers
  • monoamine oxidase inhibitors (MAOIs)

Taking some of the drugs listed above with Ozempic, may cause dangerously low blood sugar levels or increase the risk of hypoglycemia. Some may also lead to dizziness or lightheadedness due to decreased alertness associated with the combination. As such, you should talk to your healthcare provider before taking these medications while on Ozempic.

Ozempic and other medications

To take Ozempic safely while avoiding drug interaction issues, here are some steps you can take:

Always consult your healthcare practitioner before taking any new medication while on Ozempic. They will advise you if drug interactions occur and suggest alternative treatments if necessary.

Make sure you understand all potential side effects before combining any medications. Ask your healthcare practitioner about specific symptoms to look out for when taking multiple medications and when starting a new medication.

Take all prescribed medications exactly as instructed. Don’t skip doses or alter dosages without consulting your healthcare practitioner and receiving approval from them first.

Follow up regularly with a healthcare practitioner. They can check in on how you’re doing with both individual and combined drug interactions over time and can make sure everything is going smoothly and intervene if necessary. Not all drugs are compatible — including those that you must take alongside Ozempic — so always consult your healthcare practitioner before combining them to stay safe.

What foods should I avoid while on Ozempic?

Taking Ozempic to help manage blood sugar levels and weight requires a thoughtful approach to food choices. Eating certain foods or consuming too much may disrupt your blood sugar levels and reduce the medication’s effectiveness. You should discuss your diet with your healthcare practitioner to ensure you are getting the correct nutrients your body needs while maintaining the effectiveness of your medication.

Limiting your intake of sugary, processed foods is important. These items are high in sugar and may cause a rapid spike in blood sugar levels if overeaten. Limiting your intake of fatty, fried, or greasy foods such as french fries or burgers is also key since this can lead to increased cholesterol levels and weight gain over time. 

You should avoid eating high-calorie meals due to their potential negative impact on blood sugar management — instead, opt for smaller portions that are higher in fibre and nutrients like fruits, vegetables, and whole grains.

Here are some actionable steps for managing your diet while taking Ozempic:

  • Educate yourself about carbohydrates — knowing which carbohydrates contain more fibre than others will help you with your dietary choices.
  • Eat regular meals — planning balanced meals at consistent intervals throughout the day helps ensure your blood sugar stays the same from one hour to the next.
  • Avoid skipping meals — hunger pangs can easily be mistaken for low blood sugar symptoms, so always ensure you eat something.
  • Check labels when shopping — look out for sugar and fat content in packaged goods that could add up over time; ask your healthcare practitioner or nutritionist for guidance if needed.
  • Seek professional advice — consult your healthcare practitioner or registered dietitian/nutritionist about any dietary changes before making them. They can offer personalized advice tailored to suit your needs based on lab results, current medications, and other factors related to your health goals.

Your food choices are very important to successfully managing your sugar levels while on Ozempic. Keeping track of food type, portion sizes and meal timing can often improve outcomes when taken alongside a healthy lifestyle which includes regular physical activity and adequate sleep quality each night.

Ozempic and other medical conditions

If you have, or have had any of the following conditions, it is crucial to speak with your healthcare practitioner before taking Ozempic:

  • Diabetes
  • Heart disease
  • Kidney or liver disease
  • Thyroid problems
  • Pancreatitis or gallbladder problems
  • Cancer
  • Acid reflux
  • Any psychiatric disorder (such as depression, bipolar disorder, or anxiety)
  • A history of alcohol or drug abuse.

It is essential to be aware of potential interactions when taking Ozempic. Some medications and supplements that may interact with or should be monitored while on Ozempic include coffee, certain antipsychotic medications, alcohol, ibuprofen, prednisone, and certain antidepressants.

If you want more information about Ozempic, including how to get Ozempic in Canada, speak to a Felix healthcare practitioner.

WRITTEN BY
Felix Team
Updated on:
May 25, 2023
Medically reviewed by
Dr. Sarah Lasuta
Family Physician, MD, CCFP
Disclaimer

The views expressed here are those of the author and, as with the rest of the content on Health Guide, are not a substitute for professional medical advice, diagnosis, or treatment. If you have any medical questions or concerns, please talk to your healthcare practitioner.

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